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[活体肝移植的身心方面]

[Psychosomatic aspects of living donor liver transplantation].

作者信息

Erim Y, Beckmann M, Gerken G, Paul A, Senf W, Beckebaum S

机构信息

Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Essen, Deutschland.

出版信息

Chirurg. 2010 Sep;81(9):820-5. doi: 10.1007/s00104-009-1876-8.

DOI:10.1007/s00104-009-1876-8
PMID:20730409
Abstract

Living donor liver transplantation (LDLT) offers the option to reduce organ scarcity and thereby waiting list mortality. The crucial ethical problem of LDLT is the fact that the well being of a donor is being jeopardized for the improvement of quality of life of the recipient. To preserve mental health of the donors, psychosomatic evaluation should be conducted including examination of the coping capacity, the mental stability of the donor and the voluntary nature of the donation. Thus a comprehensive disclosure of information to donors is necessary. Realistic outcome expectations, family relationships without extreme conflicts, sufficient autonomy of the donor-recipient relationship and social and familiar support are predictors facilitating a favorable psychosocial outcome for the donor. Before and after LDLT the health-related quality of life of the donors is similar or increased in comparison to the general population. Psychiatric complications following LDLT can occur in 13% of the donors. Female donors, donors who have surgical complications themselves and donors with unrealistic outcome expectations should be given psychotherapeutic support before they are admitted to living liver donation. Urgent indications in the case of acute liver failure and the donation by adult children for their parents are particular stress factors. For the safety of the donor, these combinations should be avoided whenever possible.

摘要

活体肝移植(LDLT)为减少器官短缺从而降低等待名单上的死亡率提供了一种选择。LDLT的关键伦理问题在于,供体的健康正为改善受体的生活质量而受到威胁。为保护供体的心理健康,应进行心身评估,包括检查供体的应对能力、心理稳定性以及捐赠的自愿性质。因此,有必要向供体全面披露信息。现实的结果预期、没有极端冲突的家庭关系、供体 - 受体关系的充分自主性以及社会和家庭支持是促进供体获得良好心理社会结果的预测因素。与普通人群相比,LDLT前后供体的健康相关生活质量相似或有所提高。LDLT后13%的供体可能会出现精神并发症。女性供体、自身有手术并发症的供体以及结果预期不现实的供体在接受活体肝捐赠之前应给予心理治疗支持。急性肝衰竭情况下的紧急指征以及成年子女为父母捐赠是特别的压力因素。为了供体的安全,应尽可能避免这些组合情况。

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本文引用的文献

1
Cosmesis and body image after adult right lobe living liver donation.成人右半肝活体肝移植术后的美容效果和体像
Transplantation. 2010 May 27;89(10):1270-5. doi: 10.1097/TP.0b013e3181d58654.
2
Gender-specific differences associated with living donor liver transplantation: a review study.与活体供肝移植相关的性别特异性差异:综述研究。
Liver Transpl. 2010 Mar;16(3):375-86. doi: 10.1002/lt.22002.
3
A peer-based intervention to educate liver transplant candidates about living donor liver transplantation.基于同伴的教育干预,以向肝移植候选者传授活体供者肝移植的知识。
Chirurg. 2013 May;84(5):398-408. doi: 10.1007/s00104-012-2414-7.
Liver Transpl. 2010 Jan;16(1):42-8. doi: 10.1002/lt.21937.
4
Mental and physical quality of life in actual living liver donors versus potential living liver donors: a prospective, controlled, multicenter study.实际活体肝移植供体与潜在活体肝移植供体的身心生活质量:一项前瞻性、对照、多中心研究。
Liver Transpl. 2009 Dec;15(12):1676-87. doi: 10.1002/lt.21917.
5
Making sense of risk. Donor risk communication in families considering living liver donation to a child.理解风险。在考虑为儿童进行活体肝移植的家庭中进行供体风险沟通。
Med Health Care Philos. 2010 May;13(2):149-56. doi: 10.1007/s11019-009-9226-7.
6
A model of risk and protective factors influencing the postoperative course of living liver donors.影响活体肝供者术后病程的风险与保护因素模型。
Transplant Proc. 2009 Jun;41(5):1682-6. doi: 10.1016/j.transproceed.2009.02.096.
7
Sense of coherence and social support predict living liver donors' emotional stress prior to living-donor liver transplantation.连贯感和社会支持可预测活体肝移植供者在活体肝移植术前的情绪压力。
Clin Transplant. 2008 May-Jun;22(3):273-80. doi: 10.1111/j.1399-0012.2007.00782.x.
8
Selection of donors for adult living-donor liver donation: results of the assessment of the first 205 donor candidates.成人活体肝移植供体的选择:首批205名候选供体的评估结果
Psychosomatics. 2008 Mar-Apr;49(2):143-51. doi: 10.1176/appi.psy.49.2.143.
9
Liver and intestine transplantation in the United States, 1997-2006.1997 - 2006年美国的肝脏和肠道移植
Am J Transplant. 2008 Apr;8(4 Pt 2):958-76. doi: 10.1111/j.1600-6143.2008.02174.x.
10
Psychological strain in urgent indications for living donor liver transplantation.活体肝移植紧急指征中的心理压力。
Liver Transpl. 2007 Jun;13(6):886-95. doi: 10.1002/lt.21168.