Erim Y, Beckmann M, Gerken G, Paul A, Senf W, Beckebaum S
Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Essen, Deutschland.
Chirurg. 2010 Sep;81(9):820-5. doi: 10.1007/s00104-009-1876-8.
Living donor liver transplantation (LDLT) offers the option to reduce organ scarcity and thereby waiting list mortality. The crucial ethical problem of LDLT is the fact that the well being of a donor is being jeopardized for the improvement of quality of life of the recipient. To preserve mental health of the donors, psychosomatic evaluation should be conducted including examination of the coping capacity, the mental stability of the donor and the voluntary nature of the donation. Thus a comprehensive disclosure of information to donors is necessary. Realistic outcome expectations, family relationships without extreme conflicts, sufficient autonomy of the donor-recipient relationship and social and familiar support are predictors facilitating a favorable psychosocial outcome for the donor. Before and after LDLT the health-related quality of life of the donors is similar or increased in comparison to the general population. Psychiatric complications following LDLT can occur in 13% of the donors. Female donors, donors who have surgical complications themselves and donors with unrealistic outcome expectations should be given psychotherapeutic support before they are admitted to living liver donation. Urgent indications in the case of acute liver failure and the donation by adult children for their parents are particular stress factors. For the safety of the donor, these combinations should be avoided whenever possible.
活体肝移植(LDLT)为减少器官短缺从而降低等待名单上的死亡率提供了一种选择。LDLT的关键伦理问题在于,供体的健康正为改善受体的生活质量而受到威胁。为保护供体的心理健康,应进行心身评估,包括检查供体的应对能力、心理稳定性以及捐赠的自愿性质。因此,有必要向供体全面披露信息。现实的结果预期、没有极端冲突的家庭关系、供体 - 受体关系的充分自主性以及社会和家庭支持是促进供体获得良好心理社会结果的预测因素。与普通人群相比,LDLT前后供体的健康相关生活质量相似或有所提高。LDLT后13%的供体可能会出现精神并发症。女性供体、自身有手术并发症的供体以及结果预期不现实的供体在接受活体肝捐赠之前应给予心理治疗支持。急性肝衰竭情况下的紧急指征以及成年子女为父母捐赠是特别的压力因素。为了供体的安全,应尽可能避免这些组合情况。