Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil.
Neurol Sci. 2011 Feb;32(1):59-65. doi: 10.1007/s10072-010-0393-3. Epub 2010 Aug 21.
The aim of this study was to evaluate urinary uric acid (UA) and lipid peroxidation levels, plasma myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and serum UA in neonatal rats subjected to hypoxia-ischemia neonatal HI model. The relevance of the findings is the fact that urinary lipid peroxidation and UA levels were significantly higher in 8 days in HI group when compared with the control, returning to baseline levels 60 days after HI. Hence, being an indication of purinic degradation during these first days post-HI. Furthermore, the higher levels of malondialdehyde (MDA) in urine in this period may be related to inadequate scavenging abilities of the immature nervous system and being noninvasive it may suggest the use of urinary MDA measurement as a marker for lipid peroxidation after HI insult. In application terms, these findings can help develop therapeutic interventions as soon as 8 days after HI.
本研究旨在评估缺氧缺血新生 HI 模型幼鼠的尿尿酸 (UA) 和脂质过氧化水平、血浆髓过氧化物酶 (MPO) 和腺苷脱氨酶 (ADA) 活性以及血清 UA。这些发现的相关性在于，与对照组相比，HI 组在 8 天时尿脂质过氧化和 UA 水平显著升高，在 HI 后 60 天恢复到基线水平。因此，这表明 HI 后最初几天内嘌呤降解。此外，在此期间尿中丙二醛 (MDA) 水平较高可能与未成熟神经系统的清除能力不足有关，并且由于其非侵入性，因此可能表明使用尿 MDA 测量作为 HI 损伤后脂质过氧化的标志物。在应用方面，这些发现可以帮助在 HI 后 8 天内尽早开展治疗干预。
