Méhes K, Horváth I, Szakolczai I
Acta Paediatr Acad Sci Hung. 1981;22(1-2):43-7.
In a referral neonatal intensive care unit, PaO2 values of 40 newborn infants were compared with the serum and urinary uric acid levels. The latter was estimated from the first urine obtained after admission. A significant inverse correlation was found between PaO2 and serum uric acid concentration and between PaO2 and urinary uric acid per creatinine ratio, but no correlation was seen between PaO2 and urinary uric acid concentration. The urinary uric acid per creatinine ratio was determined on the 1st, 2nd and 5th days of life in 27 normal prematures, 28 hypoxic prematures, 23 normal full-term infants and 25 hypoxic full-term neonates. Significantly higher values were obtained in both hypoxic groups on the 1st day, and in hypoxic prematures even on the 2nd day. Although creatinine as a reference substance is regarded as unreliable in the neonatal period, if a single urine sample is only available, determination fo the uric acid per creatinine ratio seems to be warranted, since higher values may retrospectively point to hypoxia.
在一家转诊新生儿重症监护病房，对40名新生儿的动脉血氧分压（PaO2）值与血清及尿尿酸水平进行了比较。尿尿酸水平是根据入院后首次采集的尿液进行估算的。研究发现，PaO2与血清尿酸浓度之间、PaO2与尿尿酸/肌酐比值之间存在显著的负相关，但PaO2与尿尿酸浓度之间未发现相关性。对27名正常早产儿、28名缺氧早产儿、23名正常足月儿和25名缺氧足月儿在出生第1天、第2天和第5天测定了尿尿酸/肌酐比值。在第1天，两个缺氧组的尿尿酸/肌酐比值均显著升高，缺氧早产儿在第2天该比值仍较高。尽管肌酐作为参考物质在新生儿期被认为不可靠，但如果仅能获取单次尿液样本，测定尿尿酸/肌酐比值似乎是有必要的，因为较高的比值可能提示既往存在缺氧情况。
