Kooper Angelique J A, Smeets Dominique F C M, Feenstra Ilse, Wijnberger Lia D E, Rijnders Robbert J P, Quartero Rik W P, Boekkooi Peter F, van Vugt John M G, Smits Arie P T
Department of Human Genetics, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Obstet Gynecol Int. 2013;2013:636459. doi: 10.1155/2013/636459. Epub 2013 Apr 30.
Objectives. Pregnant women, referred because of an increased risk of fetal Down syndrome, who underwent an invasive prenatal procedure were offered a choice between karyotyping and rapid targeted testing. This study aims to assess women's attitudes and experiences towards what option to choose. Methods. A retrospective multicentre survey (2008-2010) was conducted among 1370 women. General questions were asked about decision making issues, followed by personal questions about their experiences in choice making, test preference, influence of others, and possible regrets. Results. In total, 90.1% of the respondents (N = 825) indicated that pregnant women are able to choose, although 33.1% stated that the choice can best be made by a professional. 18.4% indicated that making a choice places a burden on women. In 96.4%, respondents preferred to have the option to choose again in case of a next pregnancy, whereas 2.7% preferred the choice to be made by a professional. Regret was indicated by 1.2%. Decision making was influenced by others in 64.9%. A slightly higher preference for karyotyping was indicated by 52.7% of the respondents. Conclusions. Positive attitudes and experiences were expressed towards the option to choose. Respondents took decisions freely, although sometimes influenced by a partner or a professional, to follow their individual perspectives.
目的。因胎儿唐氏综合征风险增加而转诊的孕妇，若接受侵入性产前检查，可在核型分析和快速靶向检测之间进行选择。本研究旨在评估女性对于选择何种检查的态度和经历。方法。对1370名女性进行了一项回顾性多中心调查（2008 - 2010年）。询问了有关决策问题的一般性问题，随后是关于她们在选择过程中的经历、检查偏好、他人影响以及可能的遗憾等个人问题。结果。总共90.1%的受访者（N = 825）表示孕妇能够做出选择，尽管33.1%的人表示最好由专业人员做出选择。18.4%的人表示做出选择给女性带来负担。在96.4%的人中，受访者希望下次怀孕时能再次有选择的机会，而2.7%的人希望由专业人员做出选择。有1.2%的人表示有遗憾。64.9%的人的决策受到他人影响。52.7%的受访者对核型分析的偏好略高。结论。对选择这一选项表达了积极的态度和经历。受访者自由做出决定，尽管有时会受到伴侣或专业人员的影响，以遵循他们各自的观点。
