Arika T, Yokoo M, Maeda T, Amemiya K, Yamaguchi H
Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Tokyo, Japan.
Antimicrob Agents Chemother. 1990 Nov;34(11):2254-5. doi: 10.1128/AAC.34.11.2254.
Butenafine is a new antifungal benzylamine. The efficacy of butenafine was investigated in an experimental tinea pedis model in guinea pigs, which is pathologically similar to natural infections in humans. Butenafine (0.1 ml) in 0.2 to 1.0% solutions was applied to the site of infection. Treatment was started on day 10 postinfection and was continued for 20 days. Butenafine applied once daily exhibited excellent dose-related therapeutic efficacy. The efficacy of butenafine was significantly superior to those tolnaftate, clotrimazole, and bifonazole.
布替萘芬是一种新型抗真菌苄胺。在豚鼠实验性足癣模型中研究了布替萘芬的疗效，该模型在病理上与人类自然感染相似。将0.2%至1.0%溶液中的布替萘芬（0.1毫升）应用于感染部位。在感染后第10天开始治疗，并持续20天。每天应用一次布替萘芬显示出良好的剂量相关治疗效果。布替萘芬的疗效明显优于托萘酯、克霉唑和联苯苄唑。
