Institute of Physics, Academy of Sciences of the Czech Republic, v.v.i., Cukrovarnická 10, 162 53 Prague 6, Czech Republic.
Philos Trans A Math Phys Eng Sci. 2010 Sep 28;368(1927):4389-405. doi: 10.1098/rsta.2010.0123.
Core-shell nanoparticles consisting of La(0.75)Sr(0.25)MnO(3) cores covered by silica were synthesized by a procedure consisting of several steps, including the sol-gel method in the presence of citric acid and ethylene glycol, thermal and mechanical treatment, encapsulation employing tetraethoxysilane and final separation by centrifugation in order to get the required size fraction. Morphological studies revealed well-separated particles that form a stable water suspension. Magnetic studies include magnetization measurements and investigation of the ferromagnetic-superparamagnetic-paramagnetic transition. Magnetic heating experiments in 'calorimetric mode' were used to determine the heating efficiency of the particles in water suspension and further employed for biological studies of extracellular and intracellular effects analysed by tests of viability.
核壳纳米粒子由 La(0.75)Sr(0.25)MnO(3) 内核和二氧化硅外壳组成，通过包括以下步骤的程序合成：柠檬酸和乙二醇存在下的溶胶-凝胶法、热和机械处理、采用四乙氧基硅烷进行封装以及最后通过离心分离以获得所需的粒径。形态研究表明形成稳定水悬浮液的颗粒得到了很好的分离。磁性研究包括磁化测量和铁磁-超顺磁-顺磁转变的研究。在“量热模式”下进行的磁加热实验用于确定水悬浮液中粒子的加热效率，并进一步用于通过细胞外和细胞内效应的生存力测试进行生物研究。
