Department of Urology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, HU-390, Boston, MA 02115, USA.
Pediatrics. 2010 Sep;126(3):e576-82. doi: 10.1542/peds.2010-0747. Epub 2010 Aug 23.
Current clinical guidelines recommend that orchidopexy be performed by the age of 1 in patients with congenital undescended testis. We sought to examine trends in surgical timing and to determine what factors are associated with age at surgery.
The Pediatric Health Information System (PHIS) is a national database of >40 freestanding children's hospitals. We searched the PHIS to identify boys with cryptorchidism who underwent orchidopexy between 1999 and 2008. Patient age at orchidopexy was evaluated, and we used multivariate models to determine factors associated with timing of surgery.
We identified 28 204 children who underwent orchidopexy at PHIS hospitals. Of these, 14,916 (53%) were white, and 17,070 (61%) had public insurance. Only 5031 patients (18%) underwent orchidopexy by the age of 1 year; only 12,165 (43%) underwent orchidopexy by the age of 2 years. These figures remained stable over time (P=.32). After adjusting for patient clustering, race (P<.001) and insurance status (P<.001) remained associated with patient age at orchidopexy; however, the treating hospital (P<.001) was the most important factor in predicting the timing of the procedure.
Only 43% had surgery by 2 years of age, which suggests that either significant numbers of boys with congenital cryptorchidism do not undergo surgery in a timely fashion or late-onset testicular ectopy is more common than generally recognized. Factors associated with the timing of orchidopexy include patient race, insurance status, and the hospital in which surgery is performed.
目前的临床指南建议对患有先天性隐睾症的患者在 1 岁时进行睾丸固定术。我们试图研究手术时机的趋势,并确定与手术年龄相关的因素。
儿科健康信息系统(PHIS)是一个拥有 40 多家独立儿童医院的全国性数据库。我们在 PHIS 中搜索接受睾丸固定术的隐睾症男孩,时间范围为 1999 年至 2008 年。评估患者的睾丸固定术年龄,并使用多变量模型确定与手术时机相关的因素。
我们在 PHIS 医院确定了 28204 例接受睾丸固定术的儿童。其中,14916 例(53%)为白人,17070 例(61%)有公共保险。只有 5031 例(18%)患者在 1 岁时接受睾丸固定术;只有 12165 例(43%)患者在 2 岁时接受睾丸固定术。这些数字随时间保持稳定(P=.32)。在校正患者聚类后,种族(P<.001)和保险状况(P<.001)仍然与患者睾丸固定术年龄相关;然而,治疗医院(P<.001)是预测手术时间的最重要因素。
只有 43%的患者在 2 岁之前接受手术,这表明大量患有先天性隐睾症的男孩没有及时接受手术,或者迟发性睾丸异位比普遍认为的更为常见。与睾丸固定术时间相关的因素包括患者种族、保险状况和手术医院。