IRCCS C. Mondino Foundation, National Institute of Neurology, Pavia, Italy.
Dement Geriatr Cogn Disord. 2010;30(2):147-54. doi: 10.1159/000318842. Epub 2010 Aug 21.
Since little is known about the role of gender in the course of Alzheimer's disease (AD), a prospective epidemiological study was conducted to detect gender differences in relation to AD evolution and outcome.
Six hundred AD patients, 214 men and 386 women, first seen between September 2000 and December 2003, were enrolled; the follow-up period lasted until December 2008.
The men had greater comorbidity and higher mortality than the women, who instead recorded more disability and longer survival. Survival curves showed that women reach partial loss of autonomy faster than men. Higher Neuropsychiatric Inventory scores at baseline showed a predictive value for loss of autonomy regardless of gender. Pharmacological treatment seems to have a protective role on disability and mortality.
Gender influences disease evolution not only directly but also through other factors such as comorbidity.
由于对性别在阿尔茨海默病（AD）病程中的作用知之甚少，因此进行了一项前瞻性的流行病学研究，以检测与 AD 演变和结果相关的性别差异。
600 名 AD 患者，214 名男性和 386 名女性，于 2000 年 9 月至 2003 年 12 月间首次就诊，随访期持续至 2008 年 12 月。
男性的合并症和死亡率高于女性，而女性的残疾率和生存率更高。生存曲线显示，女性比男性更快地达到部分自主能力丧失。基线时较高的神经精神问卷评分无论性别如何，都对自主能力丧失具有预测价值。药物治疗似乎对残疾和死亡率具有保护作用。
性别不仅直接影响疾病的演变，还通过其他因素如合并症来影响。
