Conceição Sarah Dos Santos, Carvalho Delmason Soares Barbosa de, Batista Josicélia Estrela Tuy, Lyrio Amanda Oliveira, Souza Elivan Silva, Matos Paulo José Dos Santos de, Hintz Alexandre Marcelo, Cruz Simone Seixas da, Gomes-Filho Isaac Suzart, Figueiredo Ana Claudia Morais Godoy
Department of Health, University of Brasília, Brasília 70910-900, Brazil.
Health Surveillance, Department of Public Health of the Federal District, Brasília 70390-125, Brazil.
Int J Environ Res Public Health. 2023 Sep 5;20(18):6713. doi: 10.3390/ijerph20186713.
Neuropsychiatric diseases, particularly dementias, has become more prominent with a great impact on the quality of life of the elderly population.
To verify the rate of increase in mortality due to Alzheimer's disease in the Federal District, Brazil from 2010 to 2018.
An ecological study was conducted, with a time series, about the evolution of the mortality coefficient in the Federal District, Brazil carried out at the Federal District State Department of Health. Mortality rates were defined as the dependent variable and years evaluated as the independent variable-from 2010 to 2018. For temporal trend analysis, the Prais-Winsten linear regression model was used and the increment rate with the respective 95% confidence interval was estimated.
From 2010 to 2018, 1665 deaths which had Alzheimer's disease as the underlying cause were recorded in the Mortality Information System. The results showed an overall mortality rate of 6.55 deaths per 100,000 inhabitants, with a higher predominance in females, non-Black people, and those aged 80 years or older. There was an increase in the annual trend of the overall mortality coefficient in both sexes.
The findings demonstrated a significant increase in the temporal evolution of mortality due to Alzheimer's disease in the Federal District, Brazil. It was recommended to conduct original studies to evaluate the factors that can cause the disease in order to collaborate in the process of formulating policies in the area of public health and improvements in clinical practice.
神经精神疾病，尤其是痴呆症，已变得愈发突出，对老年人群的生活质量产生了重大影响。
核实2010年至2018年巴西联邦区因阿尔茨海默病导致的死亡率上升率。
在巴西联邦区卫生部开展了一项生态研究，采用时间序列分析联邦区死亡率系数的演变。将死亡率定义为因变量，将评估年份定义为自变量（2010年至2018年）。对于时间趋势分析，使用普赖斯-温斯坦线性回归模型，并估计增长率及其相应的95%置信区间。
2010年至2018年，死亡信息系统记录了1665例以阿尔茨海默病为根本死因的死亡病例。结果显示，总体死亡率为每10万居民中有6.55人死亡，女性、非黑人以及80岁及以上人群的死亡率更高。男女总体死亡率系数的年度趋势均有所上升。
研究结果表明，巴西联邦区因阿尔茨海默病导致的死亡率在时间演变上显著上升。建议开展原创性研究，以评估可能导致该病的因素，从而在公共卫生领域政策制定及临床实践改进过程中提供助力。
