严重感染全身炎症中的基因特异性表观遗传调控。
Gene-specific epigenetic regulation in serious infections with systemic inflammation.
机构信息
Translational Science Institute, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
出版信息
J Innate Immun. 2010;2(5):395-405. doi: 10.1159/000314077. Epub 2010 Apr 27.
Abstract
Inflammation is a fundamental biologic process that is evolutionally conserved by a germ line code. The interplay between epigenetics and environment directs the code into temporally distinct inflammatory responses, which can be acute or chronic. Here, we discuss the epigenetic processes of innate immune cells during serious infections with systemic inflammation in four stages: homeostasis, incitement, evolution, and resolution. We describe feed-forward loops of serious infections with systemic inflammation that create gene-specific silent facultative heterochromatin and active euchromatin according to gene function, and speculate on the role of epigenetics in survival.
摘要
炎症是一种基本的生物过程，通过种系编码得到进化保守。表观遗传学和环境之间的相互作用指导着编码进入不同的、暂时的炎症反应，这些反应可以是急性的，也可以是慢性的。在这里，我们讨论了固有免疫细胞在严重感染全身炎症时的表观遗传过程，分为四个阶段：稳态、激发、进化和解决。我们描述了全身炎症严重感染的正反馈循环，根据基因功能创造了特定基因的沉默的兼性异染色质和活跃的常染色质，并推测了表观遗传学在生存中的作用。
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