Department of Paediatric Haematology/Oncology, John Radcliffe Hospital, Oxford, UK.
Pediatr Blood Cancer. 2010 Dec 15;55(7):1402-5. doi: 10.1002/pbc.22707.
We describe a patient diagnosed with haemolytic uraemic syndrome (HUS) during long-term maintenance therapy for childhood acute lymphoblastic leukaemia (ALL). He rapidly developed renal failure, hypertension and profound thrombocytopenia. Despite suffering a large intracerebral haemorrhage, he made a full recovery without residual neurological or renal deficit. His case raises the question of whether ALL or its treatments predispose an individual to developing HUS.
我们描述了一名在儿童急性淋巴细胞白血病(ALL)长期维持治疗期间被诊断为溶血尿毒综合征(HUS)的患者。他迅速出现肾衰竭、高血压和严重血小板减少症。尽管他发生了大量颅内出血,但仍完全康复,没有留下神经或肾脏方面的缺陷。他的病例提出了这样一个问题,即 ALL 或其治疗方法是否使个体易发生 HUS。