Yilmaz Mehmet, Isaoglu Unal, Delibas Ilhan Bahri, Kadanali Sedat
Nenehatun Obstetrics and Gynecology Hospital, Erzurum, Turkey.
J Obstet Gynaecol Res. 2011 Aug;37(8):1020-6. doi: 10.1111/j.1447-0756.2010.01478.x. Epub 2011 Apr 12.
To compare all phenotypes of polycystic ovary syndrome (PCOS) for anthropometrical, hormonal, and metabolic differences according to Rotterdam criteria.
MATERIAL & METHODS: Women with PCOS (Rotterdam definition; n = 127) and women without PCOS used as controls (n = 44). There were four phenotypes of PCOS: 56/127 (44.09%) of the patients were polycystic ovaries on ultrasound (PCO) + oligo or anovulation (O) + biochemical and/or clinical hyperandrogenism (HA), 29/127 (22.84%) were HA+O, 24/127 (18.90%) were PCO+O and 18/127 (14.17%) were HA+PCO. And 42/127 (33.07%) patients represented the new phenotypes (PCO+O and HA+PCO). Phenotypical, hormonal and metabolic parameters were compared between the groups.
Waist-to-hip ratio, luteinizing hormone-to-follicle stimulating hormone ratio, testosterone, androstenedione, dehydroepiandrostenedione were lower in women with PCO+O and controls than the other three phenotypes. The highest score regarding hirsutismus was found in the HA+O phenotype and the lowest score in the PCO+O phenotype. Prevalence of metabolic syndrome and degree of insulin resistance in PCO+O phenotype was closer to control subjects than the other three phenotypes.
Anthropometrical, hormonal, and metabolic differences suggest that PCO+O phenotype is closer to control group than the other PCOS phenotypes.
根据鹿特丹标准比较多囊卵巢综合征（PCOS）所有表型在人体测量学、激素和代谢方面的差异。
患有PCOS的女性（鹿特丹定义；n = 127）以及未患PCOS的女性作为对照（n = 44）。PCOS有四种表型：56/127（44.09%）的患者超声显示多囊卵巢（PCO）+少排卵或无排卵（O）+生化和/或临床高雄激素血症（HA），29/127（22.84%）为HA+O，24/127（18.90%）为PCO+O，18/127（14.17%）为HA+PCO。42/127（33.07%）的患者表现为新表型（PCO+O和HA+PCO）。比较了各组之间的表型、激素和代谢参数。
PCO+O组女性和对照组的腰臀比、黄体生成素与促卵泡生成素比值、睾酮、雄烯二酮、脱氢表雄酮低于其他三种表型。多毛症得分最高的是HA+O表型，最低的是PCO+O表型。PCO+O表型的代谢综合征患病率和胰岛素抵抗程度比其他三种表型更接近对照组。
人体测量学、激素和代谢方面的差异表明，PCO+O表型比其他PCOS表型更接近对照组。
