Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
J Am Chem Soc. 2010 Sep 22;132(37):12856-8. doi: 10.1021/ja106203q.
The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.
报道了在具有单个锁核酸 TT 步的短单链和双链 DNA 结构中胸腺嘧啶-胸腺嘧啶光二聚化的综合实验和理论研究结果。锁核酸对基态构象的控制导致光产物形成的量子产率和选择性显著提高。
