Filipo Roberto, Covelli Edoardo, Balsamo Giorgio, Attanasio Giuseppe
Department of Neurology and Otolaryngology, ‘sapienza’ University of Rome, Italy.
Acta Otolaryngol. 2010 Nov;130(11):1209-13. doi: 10.3109/00016481003793766.
Intratympanic administration of prednisolone at a dose of 62.5 mg/ml performed every day for 3 consecutive days is more efficacious than the therapeutic approaches described so far in the literature.
The aim of the study was to evaluate the overall success rate, morbidity, and prognostic factors of a new protocol of intratympanic steroid administration as a means of primary therapy for idiopathic sensorineural hearing loss.
Overall, 34 patients presenting sudden unilateral sensorineural hearing loss of at least 30 dB over three frequencies that had developed within 72 h were treated once a day for 3 consecutive days with a single intratympanic injection of prednisone diluted in saline solution.
Following intratympanic therapy with prednisone, 16 patients (47%) reported complete recovery of sudden sensorineural hearing loss, with a pure tone average that returned within 25 dB; 11 patients (32.3%) showed improvement in hearing of more than 30 dB; 4 patients presented improvement in pure-tone average between 10 and 30 dB. Only three patients failed to improve following intratympanic injection.
连续3天每天进行鼓室内注射剂量为62.5毫克/毫升的泼尼松龙，比文献中迄今描述的治疗方法更有效。
本研究的目的是评估一种新的鼓室内注射类固醇方案作为特发性感音神经性听力损失主要治疗手段的总体成功率、发病率和预后因素。
总体而言，34例在72小时内出现至少三个频率突发单侧感音神经性听力损失至少30分贝的患者，连续3天每天接受一次鼓室内注射用生理盐水稀释的泼尼松治疗。
接受鼓室内注射泼尼松治疗后，16例患者（47%）报告突发感音神经性听力损失完全恢复，纯音平均听阈恢复到25分贝以内；11例患者（32.3%）听力改善超过30分贝；4例患者纯音平均听阈改善在10至30分贝之间。仅3例患者在鼓室内注射后未改善。
