Department of Radiation Oncology, Institut Curie, Paris cedex 05, Paris 75248, France.
Expert Rev Anticancer Ther. 2010 Aug;10(8):1215-27. doi: 10.1586/era.10.67.
Breast cancer is a rare disease in young women. Its incidence has remained remarkably constant over the last decades, contrary to what has happened in older patients. Age is a major prognostic factor for local control after breast-conserving treatments, which does not seem to be entirely explained by the poor prognostic features that are more commonly associated with breast cancers in young women. A better knowledge of the prognostic factors for local control, and, whenever possible, those pertaining specifically to the young age group, is key, not only to better select the patients who would benefit the most from a breast-conserving approach but also to enhance the local control when this option has been elected. These prognostic factors can be related to the patient, the tumor and the treatment they receive. Finally, we will present a perspective of what the future could hold, both in terms of the selection of the patients and of a more customized therapeutic approach.
乳腺癌在年轻女性中较为罕见。与老年患者不同，在过去几十年中，其发病率一直保持着显著的稳定。年龄是保乳治疗后局部控制的一个主要预后因素，但这似乎并不能完全用与年轻女性乳腺癌更常见的不良预后特征来解释。更好地了解局部控制的预后因素，以及在可能的情况下，了解专门针对年轻年龄组的预后因素，至关重要，不仅可以更好地选择最能从保乳治疗中受益的患者，还可以在选择这种治疗方法时提高局部控制率。这些预后因素可以与患者、肿瘤和他们接受的治疗有关。最后，我们将展望未来在患者选择和更个性化的治疗方法方面可能会有哪些进展。
