Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, Campinas State University, São Paulo, Brazil.
J Clin Periodontol. 2010 Dec;37(12):1100-9. doi: 10.1111/j.1600-051X.2010.01614.x. Epub 2010 Aug 24.
This study aimed to evaluate the response of proximal furcations treated with enamel matrix derivative proteins (EMD) in a 24-month follow-up.
Twelve patients presenting bilateral class II proximal furcation with vertical probing depth (PD) ≥5 mm and bleeding on probing were selected. The furcations were assigned to: a control group (n=12), open flap debridement (OFD)+EDTA and a test group (n=12) - OFD+EDTA+EMD. The gingival margin position, PD, relative vertical and horizontal clinical attachment level (RVCAL and RHCAL), vertical and horizontal bone level (VBL and HBL) and furcation closure were evaluated before treatment and after 6, 12 and 24 months.
After follow-up, no statistical difference could be seen between groups. At 24 months, the test group showed 1.9 ± 1.6 mm PD reduction whereas the control group showed 1.0 ± 1.3 mm PD reduction. RHCAL gains of the control and the test group were 0.7 ± 1.3 and 1.4 ± 0.9 mm, respectively. However, at 24 months, the test group only presented five remaining class II furcations versus 10 furcations in the control group (p<0.05).
It could be concluded that EMD therapy promoted a reduction in the number of proximal furcations presenting a diagnosis of class II after 24 months of treatment compared with OFD therapy.
本研究旨在评估使用 enamel matrix derivative proteins（EMD）治疗近中根分叉区在 24 个月随访时的反应。
选择 12 名双侧Ⅱ类近中根分叉病变，具有垂直探诊深度（PD）≥5mm 和探诊出血的患者。将根分叉分为：对照组（n=12），翻瓣清创术（OFD）+EDTA 和试验组（n=12）-OFD+EDTA+EMD。在治疗前、治疗后 6、12 和 24 个月时评估牙龈边缘位置、PD、相对垂直和水平临床附着丧失（RVCAL 和 RHCAL）、垂直和水平骨丧失（VBL 和 HBL）和根分叉闭合情况。
随访后，两组间无统计学差异。在 24 个月时，试验组 PD 减少 1.9±1.6mm，而对照组 PD 减少 1.0±1.3mm。对照组和试验组的 RHCAL 获得分别为 0.7±1.3mm 和 1.4±0.9mm。然而，在 24 个月时，试验组只有 5 个Ⅱ类根分叉保留，而对照组有 10 个（p<0.05）。
EMD 治疗可减少 24 个月治疗后近中根分叉Ⅱ类病变的数量，与 OFD 治疗相比。
