Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
Curr Opin Allergy Clin Immunol. 2010 Oct;10(5):408-17. doi: 10.1097/ACI.0b013e32833d7d2d.
Total IgE levels are considered a useful endophenotype for studying the genetics of atopic diseases. However, the role and significance of genetic factors influencing IgE regulation for atopic diseases as endpoints is unclear.
Recently, genome-wide association studies (GWASs) have been applied to atopic traits with considerable success. A total of seven published GWASs on asthma, one GWAS on eczema, and one GWAS on total IgE have reported 11 new loci. Most of these loci appear to be trait-specific. A notable exception is the Th2 cytokine cluster, where genetic variation seems to be relevant across atopic phenotypes.
GWASs have identified several novel asthma and eczema loci as well as novel loci for IgE levels. In this review, we evaluate the interrelation between these loci and summarize to which degree recent findings on IgE reflect genetic vulnerability for atopic disease.
总 IgE 水平被认为是研究特应性疾病遗传的有用的内表型。然而，影响 IgE 调节的遗传因素在特应性疾病终点作为的作用和意义尚不清楚。
最近，全基因组关联研究（GWAS）已成功应用于特应性特征。共发表了 7 项关于哮喘、1 项关于湿疹和 1 项关于总 IgE 的 GWAS，报告了 11 个新的位点。这些位点大多似乎是特定于特征的。一个值得注意的例外是 Th2 细胞因子簇，其中遗传变异似乎与特应性表型有关。
GWAS 已经确定了几个新的哮喘和湿疹位点以及 IgE 水平的新位点。在这篇综述中，我们评估了这些位点之间的相互关系，并总结了最近关于 IgE 的发现在多大程度上反映了特应性疾病的遗传易感性。
