当前 IgE 调节的概念和遗传决定因素的影响。

Current concepts of IgE regulation and impact of genetic determinants.

机构信息

Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.

出版信息

Clin Exp Allergy. 2012 Jun;42(6):852-71. doi: 10.1111/j.1365-2222.2011.03953.x.

DOI:10.1111/j.1365-2222.2011.03953.x

Abstract

Immunoglobulin E (IgE) mediated immune responses seem to be directed against parasites and neoplasms, but are best known for their involvement in allergies. The IgE network is tightly controlled at different levels as outlined in this review. Genetic determinants were suspected to influence IgE regulation and IgE levels considerably for many years. Linkage and candidate gene studies suggested a number of loci and genes to correlate with total serum IgE levels, and recently genome-wide association studies (GWAS) provided the power to identify genetic determinants for total serum IgE levels: 1q23 (FCER1A), 5q31 (RAD50, IL13, IL4), 12q13 (STAT6), 6p21.3 (HLA-DRB1) and 16p12 (IL4R, IL21R). In this review, we analyse the potential role of these GWAS hits in the IgE network and suggest mechanisms of how genes and genetic variants in these loci may influence IgE regulation.

摘要

免疫球蛋白 E（IgE）介导的免疫反应似乎针对寄生虫和肿瘤，但最广为人知的是其在过敏中的作用。正如本综述所述，IgE 网络在不同层面受到严格控制。多年来，遗传决定因素被怀疑对 IgE 调节和 IgE 水平有很大影响。连锁和候选基因研究表明，许多基因座和基因与总血清 IgE 水平相关，最近全基因组关联研究（GWAS）提供了确定总血清 IgE 水平遗传决定因素的能力：1q23（FCER1A），5q31（RAD50，IL13，IL4），12q13（STAT6），6p21.3（HLA-DRB1）和 16p12（IL4R，IL21R）。在这篇综述中，我们分析了这些 GWAS 命中在 IgE 网络中的潜在作用，并提出了这些基因座中的基因和遗传变异如何影响 IgE 调节的机制。