IgE反应性的遗传基础：与过敏性疾病的相关性。

Genetic basis of IgE responsiveness: relevance to the atopic diseases.

作者信息

Marsh D G, Neely J D, Breazeale D R, Ghosh B, Freidhoff L R, Schou C, Beaty T H

机构信息

Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.

出版信息

Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):25-8. doi: 10.1159/000236920.

DOI:10.1159/000236920

PMID:7613143

Abstract

Genetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x 10(-6)). These and other data suggest that IL4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the IL4 gene.

摘要

对11个阿米什人大家庭中的170名受试者进行的基因分析显示，5号染色体5q31.1区域的五个标记与一个控制总血清IgE水平的基因存在连锁证据。未发现这些标记与特异性IgE抗体水平之间存在连锁关系。对128对IgE抗体阴性的同胞对中的一个子集进行的总IgE分析，证实了与5q31.1存在连锁的证据，尤其是白细胞介素4（IL4）（p = 4 × 10⁻⁶）。这些数据以及其他数据表明，IL4或其附近的基因以非抗原特异性（非同源）方式调节IgE的产生，并为哮喘与IL4基因之间可能存在的联系提供了证据。