Department of Pathology and Obstetrics and Gynecology, Università degli Studi di Sassari, Sardinia, Italy.
Int J Gynecol Pathol. 2010 Sep;29(5):423-6. doi: 10.1097/PGP.0b013e3181dc7c2e.
We present a unique case of bilateral gonadoblastoma in a 23-year-old patient with Swyer syndrome. The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one. The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion. Most probably, the pathogenesis of this abdominal dissemination was iatrogenic, with implantation occurring mechanically as a result of the multiple laparoscopic biopsies performed on both of the streak gonads 2 months before the abdominal surgery. The pathogenesis of other benign abdominal implants is discussed.
我们报告了一例独特的 23 岁斯韦尔综合征患者双侧性腺母细胞瘤。双侧性腺母细胞瘤同步发生肿瘤性转化，右侧条索状性腺为Ⅰ期生殖细胞瘤，左侧为高度分化的支持细胞瘤。后者伴有无数微小的、支持细胞种植于腹膜表面，由于分化程度高、增殖活性低且无浸润，故被认为是良性的。这种腹部播散极有可能是医源性的，由于在腹部手术前 2 个月对双侧条索状性腺进行了多次腹腔镜活检，导致机械性种植。我们还讨论了其他良性腹部种植的发病机制。
