关节内骨折与创伤后骨关节炎的基础科学。
Basic science of intra-articular fractures and posttraumatic osteoarthritis.
机构信息
Department of Orthopaedic Surgery, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA.
出版信息
J Orthop Trauma. 2010 Sep;24(9):567-70. doi: 10.1097/BOT.0b013e3181ed298d.
Abstract
Intra-articular fractures represent the primary etiologic factor leading to posttraumatic osteoarthritis. The pathomechanisms linking intra-articular fractures to end-stage cartilage destruction are poorly understood. However, fracture-related chondrocyte death has been linked to posttraumatic osteoarthritis. Researchers have made significant progress in understanding the pathomechanical link between injury and chondrocyte death. This article reviews recent basic scientific progress investigating intraarticular fractures and fracture-related chondrocyte death and dysfunction.
摘要
关节内骨折是导致创伤性骨关节炎的主要病因。关节内骨折导致晚期软骨破坏的发病机制尚不清楚。然而，与骨折相关的软骨细胞死亡与创伤性骨关节炎有关。研究人员在理解损伤与软骨细胞死亡之间的病理力学联系方面取得了重大进展。本文综述了最近在研究关节内骨折和骨折相关软骨细胞死亡及功能障碍方面的基础科学进展。
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