感染。
Infection.
机构信息
Orthopaedic Trauma Institute, San Francisco General Hospital, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA 94110, USA. ortho.attending.ucsf.edu
出版信息
J Orthop Trauma. 2010 Sep;24(9):583-6. doi: 10.1097/BOT.0b013e3181eebf12.
Abstract
Musculoskeletal infection is a clinical problem with significant direct healthcare costs. The prevalence of infection after closed, elective surgery is frequently estimated to be less than 2%, but in severe injuries, posttraumatic infection rates have been reported as 10% or greater. Although clinical infections are found outside the realm of medical devices, it is clear that the enormous increase of infections associated with the use of implants presents a major challenge worldwide. This review summarizes recent advances in the understanding, diagnosis, and treatment of musculoskeletal infections.
摘要
肌肉骨骼感染是一个具有重大直接医疗成本的临床问题。闭合性择期手术后感染的发生率通常估计不到 2%，但在严重损伤中，创伤后感染率报告为 10%或更高。尽管临床感染发生在医疗器械领域之外，但很明显，与植入物使用相关的感染大量增加是全球面临的一个重大挑战。本文综述了对肌肉骨骼感染的理解、诊断和治疗的最新进展。
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Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.呼肠孤病毒激活中枢神经系统中的转化生长因子β和骨形态发生蛋白信号通路，这些通路在感染后有助于神经元存活。
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