Vinay S D, Raghu K G, Sood P P
Department of Biosciences, Saurashtra University, Rajkot, India.
Cell Mol Biol. 1990;36(5):609-23.
Methylmercury accumulation in different parts of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) in relation to the cytoarchitectural changes in myelin sheath as well as in glycosidases levels have been reported. Male albino rats were treated with low and high doses of methylmercury chloride (1 mg/kg and 10 mg/kg) N-acetyl-DL-homocysteine thiolactone (40 mg/kg and 80 mg/kg) and glutathione (100 mg/kg and 150 mg/kg) for varied time periods. The study shows a dose and duration dependent accumulation of mercury in all the CNS areas coinciding with a progressive myelin degeneration and inhibition of the glycosidases. A casual relationship between the amount of mercury accumulation and the extent of enzymes inhibition, in any particular area of CNS, could not be established. Similarly none of the antagonists is (though has been successful in recovering the enzymes and lessening the mercury burden in a few isolated cases) able to bring an absolute control value in any group.
据报道，中枢神经系统不同部位（嗅球、大脑半球、小脑、延髓和脊髓）中甲基汞的积累与髓鞘细胞结构变化以及糖苷酶水平有关。将雄性白化大鼠分别用低剂量和高剂量的氯化甲基汞（1毫克/千克和10毫克/千克）、N-乙酰-DL-高半胱氨酸硫内酯（40毫克/千克和80毫克/千克）以及谷胱甘肽（100毫克/千克和150毫克/千克）处理不同时间段。研究表明，汞在所有中枢神经系统区域的积累呈剂量和时间依赖性，同时伴有进行性髓鞘变性和糖苷酶抑制。在中枢神经系统的任何特定区域，无法确定汞积累量与酶抑制程度之间的因果关系。同样，没有一种拮抗剂（尽管在少数孤立案例中成功恢复了酶活性并减轻了汞负荷）能够使任何一组达到绝对对照值。
