Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Am J Gastroenterol. 2010 Dec;105(12):2570-7. doi: 10.1038/ajg.2010.324. Epub 2010 Aug 24.
Complications of peptic ulcer disease (PUD) are common in China. Population-based estimates of the prevalence of PUD are needed to quantify and characterize the population at risk of these complications.
As part of a large epidemiological study, 3,600 randomly selected residents of Shanghai (aged 18-80 years) were asked to undergo endoscopy and to provide blood samples for Helicobacter pylori serology. All participants also completed a general information questionnaire and Chinese versions of the reflux disease questionnaire (RDQ) and Rome II questionnaire. Associations between PUD and other factors were analyzed using a multiple logistic regression model.
In total, 3,153 individuals (87.6%) completed the survey. All underwent blood tests, and 1,030 patients (32.7%) agreed to undergo endoscopy. Results from 1,022 patients were suitable for analysis. In all, 176 participants (17.2%) had PUD (62 with gastric ulcer; 136 with duodenal ulcer). The prevalence of H. pylori infection was 73.3% in the total population and 92.6% among those with PUD. H. pylori infection was associated with the presence of PUD (odds ratio (OR), 6.77; 95% confidence interval (CI), 2.85-16.10). The majority (72.2%) of individuals with PUD had none of the upper gastrointestinal symptoms assessed by the RDQ. PUD was not significantly associated with symptom-defined gastroesophageal reflux disease (GERD) (OR, 0.80; 95% CI, 0.32-2.03), reflux esophagitis (OR, 1.46; 95% CI, 0.76-2.79) or dyspepsia (OR, 1.69; 95% CI, 0.94-3.04).
The prevalence of endoscopically confirmed PUD in this Shanghai population (17.2%) is substantially higher than in Western populations (4.1%). The majority of individuals with PUD were asymptomatic.
消化性溃疡病（PUD）在中国较为常见。需要对其人群患病率进行基于人群的评估，以量化和描述存在这些并发症风险的人群。
作为一项大型流行病学研究的一部分，上海随机选取了 3600 名年龄在 18-80 岁的居民，要求他们进行内镜检查，并提供血液样本进行幽门螺杆菌血清学检查。所有参与者还完成了一份一般信息问卷和中文版反流疾病问卷（RDQ）和罗马 II 问卷。使用多因素逻辑回归模型分析 PUD 与其他因素的关系。
共有 3153 人（87.6%）完成了调查。所有人都接受了血液检查，1030 名患者（32.7%）同意接受内镜检查。1022 名患者的结果可用于分析。共有 176 名参与者（17.2%）患有 PUD（62 例胃溃疡；136 例十二指肠溃疡）。总人群中 H. pylori 感染率为 73.3%，PUD 患者中为 92.6%。H. pylori 感染与 PUD 的存在相关（比值比（OR），6.77；95%置信区间（CI），2.85-16.10）。大多数（72.2%）患有 PUD 的患者没有 RDQ 评估的上消化道症状。PUD 与症状定义的胃食管反流病（GERD）（OR，0.80；95%CI，0.32-2.03）、反流性食管炎（OR，1.46；95%CI，0.76-2.79）或消化不良（OR，1.69；95%CI，0.94-3.04）无显著相关性。
在上海人群中，内镜确诊的 PUD 患病率（17.2%）显著高于西方人群（4.1%）。大多数患有 PUD 的患者无症状。
