Kawahara Takashi, Taguchi Hiroki, Yamagishi Takuya, Udagawa Koichi, Ouchi Hideki, Misaki Hiroshi
Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Case Rep Oncol. 2009 Nov 21;2(3):217-219. doi: 10.1159/000258964.
Our case was 65 years old. At check-up, a high PSA level of 515 ng/ml was observed, the patient was diagnosed with having clinical stage D prostate cancer and a Maximum Androgen Blockade (MAB therapy) was started. In response to the exacerbated prostate cancer, we started a therapy involving the administration of 8 mg/kg body weight of dexamethasone and 55 mg/m(2) of docetaxel every 3 weeks. After completing 8 courses, an enlargement of the bilateral adrenal tumor was observed, and after completing 12 courses, a pleural tumor was discovered and the PSA level was also increased. The patient was therefore diagnosed with having bilateral adrenal metastasis and pleural metastasis of prostate cancer through diagnostic imaging. So far, there have been no reports of multiple occurrences of prostate cancer in the adrenal glands and the pleura, thus making this case the first such case.
我们的病例为65岁男性。在检查时，观察到前列腺特异性抗原（PSA）水平高达515 ng/ml，该患者被诊断为临床D期前列腺癌，并开始进行最大雄激素阻断（MAB疗法）。针对病情加重的前列腺癌，我们开始了一种治疗方案，每3周给予8 mg/kg体重的地塞米松和55 mg/m²的多西他赛。完成8个疗程后，观察到双侧肾上腺肿瘤增大，完成12个疗程后，发现胸膜肿瘤，且PSA水平也升高。因此，通过诊断成像，该患者被诊断为前列腺癌双侧肾上腺转移和胸膜转移。迄今为止，尚无前列腺癌在肾上腺和胸膜多处发生的报道，因此该病例为首例此类病例。
