荷包牡丹碱诱发幼鼠癫痫发作：行为和皮层电活动现象的个体发生
Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena.
作者信息
Baram T Z, Snead O C
机构信息
Department of Neurology, University of Southern California, Los Angeles 90054-0700.
出版信息
Brain Res Dev Brain Res. 1990 Dec 15;57(2):291-5. doi: 10.1016/0165-3806(90)90055-4.
Abstract
The effects of bicuculline, a gamma-aminobutyric acid (GABA) antagonist, were investigated in 258 immature rats between the third and 22nd postnatal days. Behavioral and electrocorticographic events were correlated. Bicuculline induced both behavioral and electrographic seizures as early as the third postnatal day, an age when the CD50 for bicuculline was lowest, and therefore the sensitivity to it was the greatest. Bicuculline may thus be a suitable convulsant for epilepsy studies involving rats during the first postnatal week.
摘要
在出生后第3天至第22天的258只未成熟大鼠中，研究了γ-氨基丁酸（GABA）拮抗剂荷包牡丹碱的作用。行为和脑电图事件相互关联。荷包牡丹碱早在出生后第3天就诱发了行为性和脑电图癫痫发作，此时荷包牡丹碱的半数惊厥剂量（CD50）最低，因此对其敏感性最高。因此，荷包牡丹碱可能是用于出生后第一周大鼠癫痫研究的合适惊厥剂。
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