Department of Life Science and Institute of Molecular Biology, National Chung-Cheng University, Chia-Yi, Taiwan.
Dev Dyn. 2010 Oct;239(10):2522-33. doi: 10.1002/dvdy.22394.
The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is one of the main signaling pathways in eukaryotic cells. This pathway is used during diverse growth and developmental processes in multiple tissues to control cell proliferation, differentiation, survival, and apoptosis. In addition to its role during development, the JAK/STAT pathway has also been implicated in tumorigenesis. Drosophila melanogaster is a powerful genetic tool, and its eyes have been used extensively as a platform to study signaling pathways. Many reports have demonstrated that the JAK/STAT pathway plays pleiotropic roles in Drosophila eye development. Its functions and activation are decided by its interplay with other signal pathways and the epigenetic status. In this review, we focus on the functions and regulation of the JAK/STAT pathway during eye development and provide some insights into the study of this pathway in tumorigenesis.
Janus 激酶（JAK）信号转导子和转录激活子（STAT）途径是真核细胞中的主要信号通路之一。该途径在多种组织的多种生长和发育过程中被用于控制细胞增殖、分化、存活和凋亡。除了在发育过程中的作用外，JAK/STAT 途径也与肿瘤发生有关。黑腹果蝇是一种强大的遗传工具，其眼睛被广泛用作研究信号通路的平台。许多报告表明，JAK/STAT 途径在果蝇眼睛发育中发挥着多种作用。其功能和激活取决于与其他信号通路的相互作用和表观遗传状态。在这篇综述中，我们重点介绍了 JAK/STAT 途径在眼睛发育过程中的功能和调节，并为该途径在肿瘤发生中的研究提供了一些见解。
