Handa Uma, Sood Tanvi, Punia Rajpal Singh
Department of Pathology, Government Medical College and Hospital, Sector 32A, Chandigarh, India.
Diagn Cytopathol. 2010 Sep;38(9):682-4. doi: 10.1002/dc.21306.
We report on the cytopathologic findings of a Leydig cell tumor of the testis in an adult male with no evidence of endocrine dysfunction. The preoperative diagnosis was based on fine needle aspiration cytology (FNAC) and was subsequently confirmed on histomorphology. The cytologic smears were cellular and showed tumor cells arranged singly, as well as in dyscohesive clusters. The tumor cells were large, round to polygonal, with indistinct cytoplasmic margins and pale, abundant, granular to vacuolated cytoplasm. A few intranuclear Reinke's crystals that are considered pathognomonic and essential for the diagnosis were seen. The present case was of interest because of the scarcity of literature on the cytodiagnosis of this tumor. The use of FNAC for diagnosis may vitiate the need for more invasive biopsy procedures in the preoperative diagnosis of this rare testicular tumor.
我们报告了一例成年男性睾丸间质细胞瘤的细胞病理学发现，该患者无内分泌功能障碍证据。术前诊断基于细针穿刺细胞学检查（FNAC），随后经组织形态学证实。细胞学涂片细胞丰富，显示肿瘤细胞单个排列，也有松散的细胞团。肿瘤细胞大，呈圆形至多边形，胞质边缘不清，胞质淡染、丰富，呈颗粒状至空泡状。可见一些核内Reinke晶体，其被认为是该肿瘤诊断的特征性表现且对诊断至关重要。由于关于该肿瘤细胞诊断的文献较少，本病例具有一定意义。在这种罕见睾丸肿瘤的术前诊断中，使用FNAC进行诊断可能会减少对更具侵入性活检程序的需求。
