U 127 INSERM Hopital Lariboisière, 41 Bd de La Chapelle, 75010 Paris, France.
Dev Biol. 1981 Jun;84(2):286-90. doi: 10.1016/0012-1606(81)90396-1.
In mice, rabbits, and pigs, two basic types of cardiac myosin isoenzymes were found by electrophoresis of native molecules: a fast-migrating form with high Ca(2+)-dependent ATPase activity and a slow-migrating form with low activity. According to the nomenclature of J. F. Y. Hoh, P. A. McGrath, and P. T. Hale (1978, J. Mol. Cell. Cardiol. 10, 1053-1076) these forms are called, respectively, V1 and V3. In all species, myosin was essentially V3 during fetal life, while V1 appeared around the time of birth. There were species differences in adults: mice remained V1, while rabbits and pigs returned to V3 after 3 weeks of age. Adult dog, beef, and human myosins were also composed of the V3 form only.
在小鼠、兔子和猪中，通过对天然分子的电泳发现了两种基本类型的心肌球蛋白同工酶：一种迁移速度较快、Ca(2+)依赖性 ATP 酶活性高的形式和一种迁移速度较慢、活性低的形式。根据 J. F. Y. Hoh、P. A. McGrath 和 P. T. Hale（1978，J. Mol. Cell. Cardiol. 10, 1053-1076）的命名法，这些形式分别称为 V1 和 V3。在所有物种中，肌球蛋白在胎儿期基本上都是 V3，而 V1 则出现在出生前后。在成年动物中存在物种差异：小鼠保持 V1，而兔子和猪在 3 周龄后恢复到 V3。成年狗、牛肉和人肌球蛋白也仅由 V3 形式组成。
