MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, England.
Dev Biol. 1981 Jun;84(2):372-85. doi: 10.1016/0012-1606(81)90406-1.
Genetic techniques for marking single cells and their descendents are used to study the development of the Drosophila proboscis. The proboscis develops from a pair of imaginal discs which form the left and right halves of the adult organ. Each half of the proboscis is subdivided into two compartments, one positioned anterior to the other. The homeotic mutation proboscipedia transforms the distal proboscis into a pair of distal first legs or antennae. Clones of this mutation are restricted to one or the other of the two proboscis compartments and reveal a precise homology between these compartments and the anterior and posterior compartments of the thorax and eye-antenna. These results provide strong support for the hypothesis that anterior and posterior compartments reflect basic subunits of segment development in Drosophila.
遗传技术用于标记单个细胞及其后代，用于研究果蝇喙的发育。喙由一对成虫盘发育而来，形成成年器官的左右两半。喙的每一半被细分为两个隔室，一个在前一个在后。同源突变喙残化将远端喙变成一对远端的第一腿或触角。这种突变的克隆仅限于两个喙隔室中的一个或另一个，揭示了这些隔室与胸部和眼触角的前侧和后侧隔室之间的精确同源性。这些结果为前侧和后侧隔室反映果蝇分段发育基本亚单位的假设提供了有力支持。
