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[大鼠钟摆运动、听源性癫痫、僵住症和“神经质”之间阳性遗传关系的证实]

[Confirmation of a positive genetic relationship between pendulum movements, audiogenic epilepsy, catalepsy, and "nervousness" in rats].

作者信息

Barykina N N, Chugu V F, Prokudina O I, Pliusnina I Z, Kolpakov V G

出版信息

Genetika. 2007 Jul;43(7):987-93.

PMID:17899818
Abstract

Relationships between the predispositions to pendulum movements (PMs), catalepsy, and audiogenic epilepsy in the course of breeding for "nervousness" and freezing have been studied. A positive genetic relationship between PMs, catalepsy, and audiogenic epilepsy has been demonstrated. Eighty to ninety percent of rats selected for enhanced PMs (strain PM+) exhibit predisposition to audiogenic seizures, whereas this frequency in the PM-free strain (PM-) is 10-40%.

摘要

在培育“易激惹性”和僵住反应的过程中,对摆动运动倾向(PMs)、僵住反应和听源性癫痫之间的关系进行了研究。已证实PMs、僵住反应和听源性癫痫之间存在正向遗传关系。选择用于增强PMs的大鼠(PM+品系)中,80%至90%表现出听源性癫痫发作倾向,而在无PMs的品系(PM-)中,这一频率为10%-40%。

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