Department of Family Medicine, Georgetown University Medical Center, Washington, DC, USA.
J Altern Complement Med. 2010 Sep;16(9):989-93. doi: 10.1089/acm.2009.0584.
Two of the most pressing public health challenges in the United States are treating human immunodeficiency virus (HIV) infection and illegal substance use. High rates of complementary and alternative medicine (CAM) use have been reported by individuals who suffer from both of these diseases. The goal of this study was to examine the relationship between CAM use and illegal substance use in a cohort of women with HIV or at risk for HIV disease. Based on previous research, it was hypothesized that CAM use may decrease substance use.
This was a longitudinal cohort study.
The subjects comprised Women in the Women's Interagency HIV Study.
The role of CAM use in illegal substance use was examined. Due to the hierarchical structure of the dataset, logistic regression analysis adjusting for repeated measurements (generalized estimating equation model) was carried out to assess associations of CAM use and illicit drug use.
There were 2176 women included in the analysis. After excluding for marijuana use, CAM use was associated with less drug use (odds ratio 0.82; 95% confidence interval: 0.73, 0.90).
The results supported our hypothesis that CAM users are more health conscious and thus less likely to use illicit drugs. Future studies should target both specific drugs and CAM modalities to help finalize this association.
在美国,两个最紧迫的公共卫生挑战是治疗人类免疫缺陷病毒(HIV)感染和非法药物使用。患有这两种疾病的个体报告了高比例的补充和替代医学(CAM)使用。本研究的目的是在 HIV 感染或 HIV 疾病风险女性队列中检查 CAM 使用与非法药物使用之间的关系。基于先前的研究,假设 CAM 使用可能会减少物质使用。
这是一项纵向队列研究。
受试者包括妇女间艾滋病研究中的妇女。
检查了 CAM 使用在非法药物使用中的作用。由于数据集的层次结构,进行了调整重复测量的逻辑回归分析(广义估计方程模型),以评估 CAM 使用与非法药物使用的关联。
共有 2176 名妇女纳入分析。在排除大麻使用后,CAM 使用与较少的药物使用相关(比值比 0.82;95%置信区间:0.73,0.90)。
结果支持我们的假设,即 CAM 用户更关注健康,因此不太可能使用非法药物。未来的研究应该针对特定药物和 CAM 模式,以帮助确定这种关联。