Department of Otolaryngology, University Hospital of Liège, Liège, Belgium.
Curr Med Chem. 2010;17(30):3591-604. doi: 10.2174/092986710792927895.
This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.
本文将重点探讨活性氧（ROS）和活性氮（RNS）在分子和生化途径中的作用，这些途径负责调节内耳听觉部分毛细胞和螺旋神经节神经元的存活。ROS/RNS 在耳毒性中的关键作用使它们成为有效耳保护策略的潜在有价值候选物。在这篇综述中，我们描述了 ROS/RNS 的主要特征以及在耳毒性级联反应中观察到的不同氧化过程。在每一步，我们都讨论了它们作为治疗靶点的潜力，因为越来越多的能够调节 ROS/RNS 处理或靶点的化合物正在被鉴定出来。
