大鼠脊髓膜中与突触甘氨酸受体相关的士的宁结合：离子影响
Strychinine binding associated with synaptic glycine receptors in rat spinal cord membranes: ionic influences.
作者信息
Muller W E, Snyder S H
出版信息
Brain Res. 1978 May 19;147(1):107-16. doi: 10.1016/0006-8993(78)90775-8.
Ammonium salts of some anions decrease the potency of glycine in inhibiting (3H)strychnine binding associated with synaptic glycine receptors. A correspondence exists between the ability of the ammonium salts of anions to increase the IC50 of glycine in inhibiting the (3H) strychnine binding, their capacity to reduce the (3H) strychnine binding itself, and their capacity to reverse inhibitory postsynaptic potentials. The decrease of (3H)strychnine binding in the presence of chloride is abolished by sodium, while the decrease of the potency of glycine in inhibiting (3H)strychnine is not. Binding of (3H)strychnine is influenced by monovalent cations in a biphasic fashion. Concentrations of Li+, K+, and Na+ up to 150mM decrease (3H)strychnine binding, while higher concentrations of the cations increase (3H)strychnine binding. Inhibition by glycine of (3H)strychnine binding is enhanced by low concentrations of these cations.
某些阴离子的铵盐会降低甘氨酸抑制与突触甘氨酸受体相关的（3H）士的宁结合的效力。阴离子铵盐增加甘氨酸抑制（3H）士的宁结合的IC50的能力、它们降低（3H）士的宁结合本身的能力以及它们逆转抑制性突触后电位的能力之间存在对应关系。在存在氯离子的情况下，（3H）士的宁结合的减少可被钠离子消除，而甘氨酸抑制（3H）士的宁效力的降低则不能被消除。（3H）士的宁的结合受到单价阳离子的双相影响。高达150mM的Li+、K+和Na+浓度会降低（3H）士的宁结合，而更高浓度的这些阳离子会增加（3H）士的宁结合。低浓度的这些阳离子会增强甘氨酸对（3H）士的宁结合的抑制作用。
Zotero 插件