离子对激动剂和拮抗剂与毒蕈碱受体结合的影响。
The effects of ions on the binding of agonists and antagonists to muscarinic receptors.
作者信息
Birdsall N J, Burgen A S, Hulme E C, Wells J W
出版信息
Br J Pharmacol. 1979 Nov;67(3):371-7. doi: 10.1111/j.1476-5381.1979.tb08690.x.
Abstract
1 There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl- on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. 2 Larger effects were produced by T1+, La3+, and some transition metal ions.
摘要
- 钠离子、钾离子、钙离子、镁离子或氯离子对大鼠脑中拮抗剂或激动剂与毒蕈碱受体的结合没有选择性影响。发现所有这些离子的亲和力都随离子强度降低。2. 铊离子、镧离子和一些过渡金属离子产生的影响更大。
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