Breur Johannes M P J, de Graaf Marlies, Breugem Corstiaan C, Pasmans Suzanne G M A
Department of Pediatric Cardiology, Centre for Congenital Vascular Anomalies Utrecht, University Medical Centre Utrecht/Wilhelmina Children's Hospital, Lundlaan, Utrecht, The Netherlands.
Pediatr Dermatol. 2011 Mar-Apr;28(2):169-71. doi: 10.1111/j.1525-1470.2010.01224.x.
Propranolol is a new and promising treatment for hemangiomas of infancy. We report of a patient in whom steroid maintenance therapy is successfully tapered after introduction of propranolol. This patient, however, developed symptomatic hypoglycemic events presumably because of a concurrent deficiency of epinephrine and cortisol as a direct result of both beta-blockage by propranolol and adrenal insufficiency as a result of prednisone use. Extreme care should be taken in patients treated with both propranolol and prednisone as they are at increased risk of hypoglycemia.
普萘洛尔是一种用于治疗婴儿血管瘤的新型且有前景的疗法。我们报告了一名患者,在引入普萘洛尔后,其类固醇维持疗法成功减量。然而,该患者出现了有症状的低血糖事件,推测这是由于普萘洛尔的β受体阻滞作用以及泼尼松使用导致的肾上腺功能不全,直接造成了肾上腺素和皮质醇同时缺乏。对于同时接受普萘洛尔和泼尼松治疗的患者应格外小心,因为他们发生低血糖的风险增加。