Quatraro A, Consoli G, Magno M, Caretta F, Ceriello A, Giugliano D
First Faculty of Medicine, Chair of Diabetology and Dietetics, University of Naples, Italy.
Diabete Metab. 1990 Sep-Oct;16(5):449-52.
The family connection of diabetes was examined from the clinical records of 3,372 subjects who were seen, as an out patient population, within the frame of a Regional Health Program in Taranto, South Italy. The family connection of diabetes resulted from a questionnaire in which the subjects had to give informations about their disease, if present, and degrees of relationship that were directly verified by us with the examination (clinic and laboratory) of relatives said to have diabetes. From the analysis of records, it emerged that 112 patients were affected by insulin-dependent-diabetes mellitus (IDDM): 54 of them were related with at least one subject suffering from noninsulin-dependent diabetes mellitus (NIDDM), 13 with at least one subject affected by IDDM and the remaining 45 did not show any family connection. The corresponding figures found in a group of healthy control subjects, matched to IDDM patients for age, sex and BMI, were 19, 2 and 84, respectively (p less than 0.001). 34 IDDM patients were related with a first degree of relationship (parents, sons, sibs) to diabetic subjects (IDDM or NIDDM), but only 4 controls showed such a degree (p less than 0.001). These results seem to indicate that patients with IDDM have an increased family history of NIDDM.
我们从3372名受试者的临床记录中研究了糖尿病的家族关联情况。这些受试者来自意大利南部塔兰托地区健康项目框架下的门诊人群。糖尿病的家族关联情况通过问卷调查得出，受试者需提供自身疾病（若有）的信息以及亲属关系程度，我们通过对声称患有糖尿病的亲属进行检查（临床和实验室检查）来直接核实这些信息。通过对记录的分析发现，112名患者患有胰岛素依赖型糖尿病（IDDM）：其中54人与至少一名患有非胰岛素依赖型糖尿病（NIDDM）的受试者有亲属关系，13人与至少一名患有IDDM的受试者有亲属关系，其余45人未显示出任何家族关联。在一组年龄、性别和体重指数与IDDM患者相匹配的健康对照受试者中，相应的数字分别为19、2和84（p<0.001）。34名IDDM患者与糖尿病受试者（IDDM或NIDDM）有一级亲属关系（父母、子女、兄弟姐妹），但只有4名对照受试者有这种亲属关系（p<0.001）。这些结果似乎表明，IDDM患者的NIDDM家族病史有所增加。
