Mengesha B, Abdulkadir J
Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Ethiopia.
East Afr Med J. 1997 Jan;74(1):37-40.
A prospective case control study was conducted in 859 diabetic probands and 1059 nondiabetic controls. These were interviewed for history of diabetes mellitus among their first degree relatives. The protocol also included second and third degree relatives. The prevalence of diabetes mellitus in the first degree relatives of cases and controls showed a statistically significant difference (Z = 6.7564 and P = 0.00000). Similarly, the prevalence of diabetes among the second and third degree relatives of cases and controls differed significantly (Z = 2.74, P = 0.006). There were 445 non-insulin dependent diabetes mellitus (NIDDM) and 414 insulin dependent diabetes mellitus (IDDM) in the diabetic probands. There was more family history of diabetes mellitus among the first degree relatives of NIDDM than IDDM and the difference is statistically significant (Z = 4.076, P = 0000). The second and third degree relatives of NIDDM and IDDM also differed significantly (Z = 4.05, P = 00005). This study indicates that heredity plays an important role in the genesis of diabetes mellitus in Ethiopian diabetics.
对859名糖尿病先证者和1059名非糖尿病对照者进行了一项前瞻性病例对照研究。对他们进行了关于其一级亲属糖尿病病史的访谈。该方案还包括二级和三级亲属。病例组和对照组一级亲属中糖尿病的患病率显示出统计学上的显著差异（Z = 6.7564，P = 0.00000）。同样，病例组和对照组二级及三级亲属中糖尿病的患病率也有显著差异（Z = 2.74，P = 0.006）。糖尿病先证者中有445例非胰岛素依赖型糖尿病（NIDDM）和414例胰岛素依赖型糖尿病（IDDM）。NIDDM一级亲属中的糖尿病家族史比IDDM更多，且差异具有统计学意义（Z = 4.076，P = 0000）。NIDDM和IDDM的二级及三级亲属也有显著差异（Z = 4.05，P = 00005）。这项研究表明，遗传在埃塞俄比亚糖尿病患者糖尿病的发生中起重要作用。
