一种用于钯催化酰胺与芳基氯交叉偶联的高效体系。
An Efficient System For the Pd-Catalyzed Cross-Coupling of Amides and Aryl Chlorides.
作者信息
Fors Brett P, Dooleweerdt Karin, Zeng Qingle, Buchwald Stephen L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
出版信息
Tetrahedron. 2009 Aug 15;65(33):6576-6583. doi: 10.1016/j.tet.2009.04.096.
Abstract
A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields.
摘要
描述了一种基于新型联芳基膦配体（3）的催化剂，用于钯催化的酰胺与芳基氯的交叉偶联反应。该体系在这些反应中展现出了迄今为止报道的最高周转频率，尤其是对于带有邻位取代基的芳基氯底物。一系列酰胺和芳基氯成功反应，产率良好至优异。
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