钯催化碳氮偶联反应中的联芳基单膦配体：最新使用指南
Biaryl Monophosphine Ligands in Palladium-Catalyzed C-N Coupling: An Updated User's Guide.
作者信息
Ingoglia Bryan T, Wagen Corin C, Buchwald Stephen L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
出版信息
Tetrahedron. 2019 Aug 9;75(32):4199-4211. doi: 10.1016/j.tet.2019.05.003. Epub 2019 May 11.
Abstract
Over the past three decades, Pd-catalyzed cross-coupling reactions have become a mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines have shown wide utility in forming C-N bonds under mild reaction conditions. This work summarizes a variety of C-N cross-coupling reactions using biaryl monophosphines as supporting ligands, with the goal of directing synthetic chemists towards the ligands and conditions best suited for a particular coupling.
摘要
在过去三十年中，钯催化的交叉偶联反应已成为有机合成的支柱。特别是，衍生自联芳基单膦的催化剂在温和反应条件下形成碳-氮键方面显示出广泛的用途。这项工作总结了使用联芳基单膦作为配体的各种碳-氮交叉偶联反应，目的是引导合成化学家找到最适合特定偶联反应的配体和条件。
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