Neetu G, Pathmanathan R, Weng Ngun Kok
Department of Pathology, Monash University Sunway Campus, Bandar Sunway, Selangor, Malaysia.
Case Rep Oncol. 2010 Jul 16;3(2):245-251. doi: 10.1159/000318641.
Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed.
糖尿病性乳腺病是一种罕见的纤维炎性乳腺疾病，其特征为淋巴细胞性小叶炎、导管炎以及伴有间质纤维化的血管周炎。这种病变在长期的1型糖尿病和其他自身免疫性疾病中常表现为可触及的单侧或双侧肿块。我们报告一例胰岛素依赖型糖尿病性乳腺病病例，该病例临床上表现为可疑恶性的不确定乳腺肿块。患者为一名36岁患有1型胰岛素依赖型糖尿病的女性。乳腺X线摄影和超声检查怀疑为恶性，遂进行了切除活检。之前的活检未发现恶性证据。现在组织病理学检查显示有致密的瘢痕疙瘩样间质纤维化，伴有上皮样和梭形肌成纤维细胞，以及小叶和导管内外血管周围特征性的淋巴细胞浸润，这些特征符合糖尿病性乳腺病。本文对相关文献进行了简要综述。
