Rahman Mashiur, East George
Department of Textile Industries, University of Leeds, Leeds - England.
J Appl Biomater Biomech. 2009 Sep-Dec;7(3):185-93.
The rate of alkaline hydrolysis of medical grade poly(ethylene terephthalate) of grey, scoured, and solvent extracted samples have been studied to understand their degradation behavior during surface modification which is used to produce antithrombus grafts.
The changes in properties were examined using weight loss, mechanical properties loss and infrared spectrum.
It was found that the rate of hydrolysis of grey sample was always slower than the scoured, and solvent extracted samples. The slower rate of degradation of the grey polyester is attributed to the presence of spin finishes in the polyester biomaterials. Further, different scouring methods also gave samples with varying rates of hydrolysis. This is due to the different spin finish removal efficiency of different scouring procedures. The weight loss (%) of the solvent extracted samples were the largest which demonstrated that the solvent extraction technique is perhaps the best to remove spin finish from the polyester.
Thus, these results serve as foundation for polyester biomaterials which are hydrolyzed before implantation in order to improve the protein binding capabilities to minimize thrombosis.
研究了灰色、精练和溶剂萃取样品的医用级聚对苯二甲酸乙二酯的碱性水解速率，以了解其在用于生产抗血栓移植物的表面改性过程中的降解行为。
使用失重、力学性能损失和红外光谱来检测性能变化。
发现灰色样品的水解速率总是比精练和溶剂萃取样品慢。灰色聚酯降解速率较慢归因于聚酯生物材料中存在纺丝油剂。此外，不同的精练方法也得到了水解速率不同的样品。这是由于不同精练程序去除纺丝油剂的效率不同。溶剂萃取样品的失重（%）最大，这表明溶剂萃取技术可能是从聚酯中去除纺丝油剂的最佳方法。
因此，这些结果为聚酯生物材料提供了基础，这些材料在植入前进行水解以提高蛋白质结合能力，从而最大限度地减少血栓形成。
