Boccazzi A, Fusi G, Mezzopane A M, Maretti M, Careddu P
First Pediatric Department, Milan University, Italy.
J Antimicrob Chemother. 1990 Nov;26 Suppl C:83-7. doi: 10.1093/jac/26.suppl_c.83.
The single-dose pharmacokinetics of cefodizime were studied in ten hospitalized children aged between two and 15 years and weighing 12.5-26.2 kg. Six subjects received the drug (25 mg/kg) im and four received it iv. Cefodizime concentrations in blood and urine (iv dosage only) sampled up to 12h post dose were measured by microbiological assay and pharmacokinetic parameters were derived on the basis of a two-compartment open model. Peak serum concentrations were 131 +/- 22.7 mg/l (15 min post iv dose) and 54.8 +/- 17.8 mg/l (60 min post im dose). Mean T1/2 beta were 1.9 +/- 0.13 h (iv) and 1.88 +/- 0.25 h (im). Mean AUCs were 217.2 +/- 37.9 mg.h/l (iv) and 150.85 +/- 22.98 mg.h/l (im). Mean volumes of distribution were 7.6 +/- 2.5 l (iv) and 7.9 +/- 1.41 (im). Twelve hours after the iv administration the cumulative urinary excretion was 78-87% of the dose. The pharmacokinetic behaviour of cefodizime in children is thus similar to that of other compounds in this class.
对10名年龄在2至15岁、体重12.5至26.2千克的住院儿童进行了头孢地嗪单剂量药代动力学研究。6名受试者接受肌肉注射该药（25毫克/千克），4名受试者接受静脉注射。采用微生物测定法测定给药后12小时内采集的血液和尿液（仅静脉给药剂量）中的头孢地嗪浓度，并基于二室开放模型推导药代动力学参数。静脉注射给药后15分钟血清峰浓度为131±22.7毫克/升，肌肉注射给药后60分钟血清峰浓度为54.8±17.8毫克/升。平均β半衰期静脉注射为1.9±0.13小时，肌肉注射为1.88±0.25小时。平均曲线下面积静脉注射为217.2±37.9毫克·小时/升，肌肉注射为150.85±22.98毫克·小时/升。平均分布容积静脉注射为7.6±2.5升，肌肉注射为7.9±1.41升。静脉给药12小时后，累积尿排泄量为给药剂量的78%至87%。因此，头孢地嗪在儿童中的药代动力学行为与该类其他化合物相似。
