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单次静脉注射和肌肉注射1.0克头孢地嗪后的药代动力学。

The pharmacokinetics of cefodizime following intravenous and intramuscular administration of a single dose of 1.0 g.

作者信息

Bryskier A, Procyk T, Tremblay D, Lenfant B, Fourtillan J B

机构信息

Institut Roussel-Uclaf, Romainville, France.

出版信息

J Antimicrob Chemother. 1990 Nov;26 Suppl C:59-63. doi: 10.1093/jac/26.suppl_c.59.

DOI:10.1093/jac/26.suppl_c.59
PMID:2074252
Abstract

The pharmacokinetics and absolute bioavailability of cefodizime were determined after iv and im administration of a single 1.0 g dose in eight healthy volunteers. The absolute bioavailability of cefodizime after im injection of 1.0 g was 88% and 91% when determined by two different formulae.

摘要

在8名健康志愿者单次静脉注射和肌内注射1.0 g剂量的头孢地嗪后,测定了其药代动力学和绝对生物利用度。通过两种不同公式测定,肌内注射1.0 g头孢地嗪后的绝对生物利用度分别为88%和91%。

相似文献

1
The pharmacokinetics of cefodizime following intravenous and intramuscular administration of a single dose of 1.0 g.单次静脉注射和肌肉注射1.0克头孢地嗪后的药代动力学。
J Antimicrob Chemother. 1990 Nov;26 Suppl C:59-63. doi: 10.1093/jac/26.suppl_c.59.
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引用本文的文献

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Clin Pharmacokinet. 1992 Mar;22(3):169-210. doi: 10.2165/00003088-199222030-00002.
2
Pharmacokinetic profile of cefodizime.头孢地嗪的药代动力学特征。
Infection. 1992;20 Suppl 1:S14-7. doi: 10.1007/BF01709944.
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Future directions in antimicrobial chemotherapy.抗菌化疗的未来发展方向。
Pharm Weekbl Sci. 1992 Aug 21;14(4A):229-44. doi: 10.1007/BF01962545.
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Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.头孢地嗪:抗菌活性、药代动力学特性及治疗用途综述
Drugs. 1992 Nov;44(5):800-34. doi: 10.2165/00003495-199244050-00008.