Winokur T S, Palazzo J P, Johnson W C, Duray P H
Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
J Cutan Pathol. 1990 Dec;17(6):342-7. doi: 10.1111/j.1600-0560.1990.tb00110.x.
As many as 40% of all primary cutaneous melanomas can have histologic remnants of nevomelanocytic nevi adjacent to the tumor. There is increasing evidence that dysplastic nevi are at least a clinical marker for melanoma risk. Spitz nevi are not known for such an association, but are noteworthy because of their histologic appearances. Spitz and dysplastic nevi were studied by flow cytometry to search for DNA abnormality. The study material consisted of formalin-fixed, paraffin embedded material of 41 dysplastic nevi and 14 Spitz nevi. Four cases of dysplastic nevi were excluded for technical reasons. Of the 37 interpretable histograms from dysplastic nevi, 28 (76%) were diploid and nine (24%) were aneuploid. All the Spitz nevi were diploid. Thus, dysplastic nevi, but not Spitz nevi, share aneuploidy features in some cases with melanoma. Previous authors have demonstrated aneuploidy in melanoma with aggressive behavior and in those in deep vertical growth phase. Aneuploidy may be a feature of early as well as late stages of tumor progression regarding the nevomelanocyte system.
所有原发性皮肤黑色素瘤中，多达40%在肿瘤旁可能有痣黑素细胞痣的组织学残留。越来越多的证据表明，发育异常痣至少是黑色素瘤风险的一个临床标志物。Spitz痣不存在这种关联，但因其组织学表现而值得关注。通过流式细胞术对Spitz痣和发育异常痣进行研究以寻找DNA异常。研究材料包括41例发育异常痣和14例Spitz痣的福尔马林固定、石蜡包埋材料。4例发育异常痣因技术原因被排除。在37例可解释的发育异常痣直方图中，28例（76%）为二倍体，9例（24%）为非整倍体。所有Spitz痣均为二倍体。因此，发育异常痣而非Spitz痣在某些情况下与黑色素瘤具有非整倍体特征。先前的作者已在具有侵袭性行为的黑色素瘤以及处于深部垂直生长期的黑色素瘤中证实了非整倍体现象。就痣黑素细胞系统而言，非整倍体可能是肿瘤进展早期及晚期的一个特征。
