Slater S D, Cook M G, Fisher C, Wright N A, Foster C S
Department of Histopathology, RPMS, Hammersmith Hospital, London, UK.
Histopathology. 1991 Oct;19(4):337-44. doi: 10.1111/j.1365-2559.1991.tb00048.x.
Cell proliferation indices and DNA content have been determined in 18 intradermal naevi, 40 dysplastic naevi and 16 superficial malignant melanomas (less than 0.76 mm depth of invasion) using flow cytometry. In this study, proliferation indices of intradermal naevi and dysplastic naevi were not significantly different from each other. Abnormalities of DNA ploidy were not identified in the intradermal naevi or dysplastic naevi; whereas three of the malignant melanomas were aneuploid. In addition, cellular proliferation was increased within the group of malignant melanomas, in comparison with the naevi. This study has found no evidence to indicate that sporadic dysplastic naevi were more likely than intradermal naevi to transform to malignant melanoma, when objective criteria were employed. However, dysplastic naevi could be distinguished from some early malignant melanomas by absence of aneuploidy and by low cell proliferation indices.
使用流式细胞术测定了18例皮内痣、40例发育异常痣和16例浅表恶性黑色素瘤（浸润深度小于0.76mm）的细胞增殖指数和DNA含量。在本研究中，皮内痣和发育异常痣的增殖指数彼此无显著差异。在皮内痣或发育异常痣中未发现DNA倍体异常；而3例恶性黑色素瘤为非整倍体。此外，与痣相比，恶性黑色素瘤组的细胞增殖增加。当采用客观标准时，本研究没有发现证据表明散发性发育异常痣比皮内痣更易转变为恶性黑色素瘤。然而，发育异常痣可通过不存在非整倍体和低细胞增殖指数与一些早期恶性黑色素瘤相区分。
