Saengsirinavin C, Kraivaphan P
Faculty of Dentistry, Mahidol University, Bangkok.
J Dent Assoc Thai. 1990 Jan-Feb;40(1):15-20.
A large number of local anesthetics has been marketed for clinical use. The purpose of this study was to compare the effectiveness of nine local anesthetics used in dentistry. After subcutaneous injection of 0.1 ml of local anesthetic into the guinea pig's back, the onset and duration of action were determined by stimulating with an electric current. The onset of action of these local anesthetics occurred immediately. But the duration of action was statistically significant different (P less than 0.01, ANOVA and Duncan's New Multiple Range Test). The duration of action ranging from 7.0 to 73.2 minutes was divided into 5 groups as the following: 1. Benadryl and Xylocaine plane. 2. Xylocaine plane and Lidocaton. 3. Citanest and Octocaine. 4. Octocaine and Neo-lidocaton. 5. Neo-lidocaton, Xylestesin-F, Xylocaine c noradrenaline 1:50,000 and Xylocaine c adrenaline 1:80,000. The result of this study will be useful for the dentists to select the appropriate local anesthetics for their treatment.
大量局部麻醉剂已投放市场用于临床。本研究的目的是比较牙科中使用的九种局部麻醉剂的有效性。在豚鼠背部皮下注射0.1毫升局部麻醉剂后，通过电流刺激来确定起效时间和作用持续时间。这些局部麻醉剂的起效时间立即出现。但作用持续时间在统计学上有显著差异（P小于0.01，方差分析和邓肯新复极差检验）。作用持续时间为7.0至73.2分钟，分为以下5组：1. 苯海拉明和利多卡因组。2. 利多卡因组和利多卡因。3. 辛可卡因和奥索卡因。4. 奥索卡因和新利多卡因。5. 新利多卡因、赛来斯汀 - F、含1:50,000去甲肾上腺素的利多卡因和含1:80,000肾上腺素的利多卡因。本研究结果将有助于牙医为其治疗选择合适的局部麻醉剂。
