• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The association between mutagenicity and adduct formation of 1,2,7,8-diepoxyoctane and 1,2,5,6-diepoxycyclooctane.

作者信息

Huang S L, Rader D N, Lee C Y

出版信息

Chem Biol Interact. 1978 Mar;20(3):333-40. doi: 10.1016/0009-2797(78)90111-4.

DOI:10.1016/0009-2797(78)90111-4
PMID:207451
Abstract

The mutagenicity of 1,2,5,6-diepoxycyclooctane (DECO) and 1,2,7,8-diepoxyoctane (DEO) was investigated using diploid Chinese hamster lung cells. 6-thioguanine (6-TG) resistance was used as the marker for mutagenicity testing: DEO was found to be genetically active; DECO, on the contrary, totally inactive. DEO readily formed adducts with radiolabeled nucleotides, while DECO failed to do so, as demonstrated through thin-layer chromatography (TLC) and the shift of the ultraviolet absorption maximum in DEO/nucleotide mixtures. The difference between the two compounds in chemical and genetic activities was attributed to their molecular conformations and the resulting differential flexibilities and adduct-forming abilities. Association between mutagenicity and adduct formation was conclusive.

摘要

相似文献

1
The association between mutagenicity and adduct formation of 1,2,7,8-diepoxyoctane and 1,2,5,6-diepoxycyclooctane.
Chem Biol Interact. 1978 Mar;20(3):333-40. doi: 10.1016/0009-2797(78)90111-4.
2
Mutagenic activities of 1,2,7,8-diepoxyoctane in Chinese hamster lung cells.
J Environ Pathol Toxicol. 1979 Jan-Feb;2(3):587-99.
3
The mutagenic action of aliphatic epoxides.脂肪族环氧化物的诱变作用。
Mutat Res. 1981 Aug;89(4):269-82. doi: 10.1016/0165-1218(81)90108-7.
4
Miscoding properties of 6alpha- and 6beta-diastereoisomers of the N(2)-(estradiol-6-yl)-2'-deoxyguanosine DNA adduct by Y-family human DNA polymerases.Y 家族人类 DNA 聚合酶对 N(2)-(雌二醇-6-基)-2'-脱氧鸟苷 DNA 加合物的 6alpha-和 6beta-非对映异构体的错配性质。
Biochemistry. 2008 Jun 24;47(25):6695-701. doi: 10.1021/bi7022255.
5
Mutagenicity of aliphatic epoxides.
Mutat Res. 1978 Nov;58(2-3):217-23. doi: 10.1016/0165-1218(78)90012-5.
6
Proceedings: Differential mutagenicity of epoxides.
Naunyn Schmiedebergs Arch Pharmacol. 1975;287 Suppl:R75.
7
Pores in the outer membrane of Escherichia coli K12: involvement of proteins b and e in the functioning of pores for nucleotides.
Mol Gen Genet. 1978 Feb 7;159(1):75-83. doi: 10.1007/BF00401750.
8
In vitro mutagenicity and cell transformation screening of phenylglycidyl ether.苯基缩水甘油醚的体外诱变性和细胞转化筛选
Mutat Res. 1979 May;67(1):9-19. doi: 10.1016/0165-1218(79)90094-6.
9
High mutagenicity and toxicity of a diol epoxide derived from benzo(a)pyrene.
Biochem Biophys Res Commun. 1976 Feb 9;68(3):1006-12. doi: 10.1016/0006-291x(76)91246-8.
10
Alkylation of nucleic acid bases by epoxides and glycidyl ethers.
Dev Toxicol Environ Sci. 1980;8:241-4.

引用本文的文献

1
Epoxides--is there a human health problem?环氧化合物——存在人类健康问题吗？
Br J Ind Med. 1980 Nov;37(4):317-36. doi: 10.1136/oem.37.4.317.