Gabow P A, Chapman A B, Johnson A M, Tangel D J, Duley I T, Kaehny W D, Manco-Johnson M, Schrier R W
University of Colorado School of Medicine, Denver.
Kidney Int. 1990 Dec;38(6):1177-80. doi: 10.1038/ki.1990.330.
Hypertension has been reported to occur in 50 to 75 percent of subjects with autosomal dominant polycystic kidney disease (ADPKD) prior to the onset of marked renal insufficiency but concurrent with cystic deformation of the renal parenchyma. The present study was undertaken to examine whether the renal structural abnormalities are greater in hypertensive (HBP) versus normotensive (NBP) male and female patients with ADPKD who were matched within gender groups for age, body surface area, serum creatinine concentration (males HBP 1.2 +/- 0.02 vs. NBP 1.1 +/- 0.03 mg/dl. NS: females HBP 0.9 +/- 0.03 vs. NBP 0.9 +/- 0.02 mg/dl, NS) and creatinine clearance (males HBP 100 +/- 3 vs. NBP 108 +/- 3 ml/min/1.73 m2, NS: females HBP 97 +/- 3 vs. NBP 96 +/- 2 ml/min/1.73 m2, NS). Renal volume was significantly greater in the HBP compared to the NBP group (males HBP 624 +/- 47 vs. NBP 390 +/- 43 cm3, P less than 0.0005; females HBP 446 +/- 32 vs. NBP 338 +/- 24 cm3, P less than 0.002). Since increased renal volume is due to increased cysts, the results indicate that the early high incidence of hypertension in ADPKD correlates with the renal structural abnormalities in this disorder.
据报道，在常染色体显性遗传性多囊肾病（ADPKD）患者中，50%至75%的患者在出现明显肾功能不全之前，但与肾实质的囊性变形同时发生高血压。本研究旨在检查在年龄、体表面积、血清肌酐浓度（男性高血压组1.2±0.02 vs. 正常血压组1.1±0.03 mg/dl，无显著差异：女性高血压组0.9±0.03 vs. 正常血压组0.9±0.02 mg/dl，无显著差异）以及肌酐清除率（男性高血压组100±3 vs. 正常血压组108±3 ml/min/1.73 m²，无显著差异：女性高血压组97±3 vs. 正常血压组96±2 ml/min/1.73 m²，无显著差异）方面进行性别匹配的高血压（HBP）和正常血压（NBP）的ADPKD男性和女性患者中，肾脏结构异常是否更严重。与NBP组相比，HBP组的肾脏体积显著更大（男性HBP组624±47 vs. NBP组390±43 cm³，P<0.0005；女性HBP组446±32 vs. NBP组338±24 cm³，P<0.002）。由于肾脏体积增加是由于囊肿增多，结果表明ADPKD中高血压的早期高发病率与该疾病的肾脏结构异常相关。
