Ohno A, Ohta Y, Ohtomo K, Hirata K, Takatsuki K, Mochida S, Ogata I, Itai Y, Iio M, Fujiwara K
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Radiat Med. 1990 Sep-Oct;8(5):159-63.
In 21 patients with chronic liver disease, the ratio of liver to muscle signal intensity on T1-weighted images was negatively correlated with the progression of hepatic fibrosis defined according to findings by laparoscopy and liver biopsy, and differentiated six patients with early chronic hepatitis from eight with liver cirrhosis. On T2-weighted images, the number of low intensity nodules comparable in size to regenerating nodules surrounded by connective tissues showed a positive correlation with stage. When hepatic fibrosis with no necrosis or fat infiltration was induced in rats, T2 values were positively correlated with hepatic hydroxyproline content, though there was no such correlation for T1 values. These results suggest that MR imaging may be useful for determining the progression of hepatic fibrosis in chronic liver disease. T2 values may directly reflect hepatic fibrosis.
在21例慢性肝病患者中，T1加权图像上肝脏与肌肉信号强度之比与根据腹腔镜检查和肝活检结果定义的肝纤维化进展呈负相关，并且能够将6例早期慢性肝炎患者与8例肝硬化患者区分开来。在T2加权图像上，与结缔组织包绕的再生结节大小相当的低强度结节数量与分期呈正相关。当在大鼠中诱导出无坏死或脂肪浸润的肝纤维化时，T2值与肝脏羟脯氨酸含量呈正相关，而T1值则无此相关性。这些结果表明，磁共振成像可能有助于确定慢性肝病中肝纤维化的进展。T2值可能直接反映肝纤维化。
